Yes, that’s comedian A.D. Miles, on fire, running away from an exploding mobile home. The photo comes courtesy of director Michael Blieden, who worked with Miles and Zach Galifianakis
on the pilot "Speed Freaks" for Comedy Central. As Blieden notes on his site, The Claw Productions: "This image has not been photoshopped at all, so yes, A.D. Miles was really on fire. Zach totally kept his cool, and the camera you see in the center of the frame was shooting slow motion. We had only one take to get this right and as you can see there were a lot of elements to coordinate."
For further evidence, here is the description of the pilot episode from Comedy Central’s development slate for 2008/2009:
A scripted show starring Zach Galifianakis and A.D. Miles
about two small town losers who are on the run from a redneck mafia
hit-man after blowing up a local meth lab. As they fumble around the
south trying to find odd jobs and shelter, the faceless hit-man is
always hot on their trail.
Let’s hope this gets on the air.